newSynthetic Biology Workshop for Secondary Schools

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October 25, 2011


CUHK Undergraduate Students Win Gold Medal at iGEM Asia
Heading to US Next Month for World Championship

A genetic engineering team formed by undergraduate students of science and engineering at The Chinese University of Hong Kong (CUHK) recently won a gold medal at the iGEM  (international Genetic Engineered Machine) Asia Regional Jamboree. They also won the Best BioBrick Measurement Approach and the Best New BioBrick Part (Natural) awards and were qualified to participate in the world championship of the iGEM Jamboree to be held at the Massachusetts Institute of Technology (MIT) in November, competing with over 50 teams from around the world. Prof. Ng Cheuk-yiu, Dean of Science; Prof. K.F. Wong, Associate Dean of Engineering; and Prof. Chu Ka-hou, Director of School of Life Sciences, today (25 October) presented certificates to the winning students in recognition of their outstanding performance. 

The CUHK team comprises seven coaches and 24 undergraduate students, including 19 life sciences students, four engineering students and one chemistry student. This is the second year that CUHK students have participated in the competition. While participants last year were all from the School of Life Sciences, engineering students from Biomedical Engineering, Computer Science and Engineering and Electronic Engineering also joined the competition this year to conduct interdisciplinary synthetic biological research. With the theme of renewable energy, the CUHK team studied how the use of solar energy could solve certain problems in two major environmental issues: water and energy. Based on the idea that a bacterial halorhodopsin can use solar energy to drive the transport of chloride ion across the membrane, the team used sunlight to drive the ion channel to concentrate ion or desalt seawater for freshwater production and create electric current to produce electricity simultaneously. 

The students' work was greatly acclaimed by the panel of judges. One of the judges, Prof. Mukund Tattai of the National Centre for Biological Sciences (India), who presented the team with the Best BioBrick Measurement Approach award, commented that the team had done extensive characterizations to the BioBrick which is well ready for use by the research community.  Another panel judge, Prof. Qi Ouyang of Peking University, who presented the team with the Best New BioBrick Part (Natural) award, commended the team's creativity in making use of an ion transporter found in bacteria to generate electricity. 

This is the first time that regional competitions of iGEM have been held in the US, Europe and Asia. A total of 42 teams from different universities joined the competition in Asia. Since this May, the CUHK team had been devoted to preparing for the competition and developed the project completely by themselves, from defining themes, designing experiments to developing new parts, models and biobricks from scratch. They demonstrated ample team spirit and efforts included publishing a wiki page, producing posters and introducing the project and the new devices on public occasions.

Prof. Chu Ka-hou emphasized that experiential learning beyond classroom was very important in nurturing talents. During the competition, students not only got an opportunity to show their creativity, but also learned the basic experimental skills through making biobricks or software. It also helped enhance their team spirit and time management skills. A biochemistry student, Gordon Chan, said, 'iGEM offers us a rare opportunity to use some state-of-the-art technological instruments and polish skills that are beyond the formal curriculum, including experimental techniques, writing skills, leadership skills, social skills, statistical analysis and presentation skills. The heavy workload also trained up my perseverance.' 

About iGEM Competition

iGEM is an annual premier synthetic biology competition for undergraduates worldwide. It was established by the MIT in 2004 to foster students' learning in synthetic biology, promote collaboration among students and nurture biology talents. Participating teams are required to specify, design, build, and test simple biological systems made from standard, interchangeable biological parts. The accomplishments of these student teams often lead to important advances in medicine, energy, and the environment. For more information, please visit http://www.igem.org.

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中大本科生奪國際遺傳工程機器設計競賽亞洲區金獎 
下月赴美參加世界賽


由香港中文大學(中大)理學院及工程學院本科生組成的基因工程隊伍日前在國際遺傳工程機器設計競賽(iGEM)的亞洲區比賽中榮獲金獎,並同時獲頒最佳生物新天然零件及最佳零件實驗量度兩項大獎,取得晉身世界賽的入場券,將於下月赴美國麻省理工學院參加iGEM決賽,與全球五十多隊隊伍一較高下。中大理學院院長伍灼耀教授、工程學院副院長黃錦輝教授和生命科學學院院長朱嘉濠教授今天(10月25日)頒發獎狀予各得獎同學,並讚揚他們的傑出表現。 

中大隊伍由七名教練及廿四名同學組成,包括十九名生命科學學院的學生、四名工程學院學生及一名化學系學生。中大生命科學學院去年首度參賽,今年更首度加入工程學院的學生,他們分別來自生物醫學工程學課程、計算機科學與工程學系和電子工程學系,與理學院學生一起進行跨學科的合成生物學研究。中大隊伍的參賽項目以再生能源為題,使用太陽能改善水源和能源兩大環境問題。基於細菌內的感光離子通道可透過太陽能來輸送氯離子,中大隊伍開發的項目利用太陽光照促使細菌吸收離子,一方面吸走水中鹽份有助海水化淡,同時可產生電流來發電。 

評審小組對中大的項目讚賞不已,來自印度國立生物科學中心的達泰牧艾教授在頒發最佳零件實驗量度大獎時表示,中大隊伍所開發的生物零件經過同學的詳細分析後,現已適合提供給其他研究人員使用。另一評審,來自北京大學的歐陽頤教授在頒發生物新天然零件大獎時,特別讚揚使用細菌感光離子通道來發電的構思十分具創意。

今年,賽會首次在美洲、歐洲及亞洲舉辦iGEM分區賽,亞洲區共有四十二隊來自不同大學的隊伍參賽。中大隊伍自今年五月起積極籌備比賽,由訂定題目、設計實驗,到創造生物零件、模型及化學零件,皆完全由同學自行構思。隊員分工合作,既順利完成了實驗,還在互聯網上發表維基網頁、印製海報,並在公開演說中講解其構思的課題及創作的新零件。 

朱嘉濠教授強調,課堂以外的學習經歷對培養人才十分重要,是次比賽為同學提供發揮無限創意的空間,讓他們在親自製作生物零件或編寫軟件的過程中學會基礎實驗的技術,更實踐了時間管理及團隊精神。來自生化課程的陳灝晴同學表示:「iGEM比賽讓我有機會使用一般本科生難以接觸到的嶄新科技儀器和技術,還可學習到多項課程外的技巧,如做實驗、寫作、領導能力、社交、統計分析、表達技巧等;繁重的工作量亦使我的毅力得到很好的鍛鍊。」 

iGEM比賽簡介

iGEM比賽為國際合成生物學界每年一度的盛事,專為本科生而設。iGEM由麻省理工學院於2004年創立,旨在促進學生在合成生物學的學習、交流與合作,以培養合成生物學人才。比賽隊伍須利用基本且可交替的生物部件,設計及建立有效的生物系統。參賽作品水平超卓,有效推動醫學、能源及環境等方面的發展。網址:http://www.igem.org

iGEM 2011 cover2


>> iGEM CUHK Team website
>> Team Members
>> More Photos

 

 

Biochemistry Students Win Gold at MIT Competition
for Proving Bacteria DNA as Device for Information Storage
(24 Nov. 2010)

 A team of 11 students from the Biochemistry programme of the School of Life Sciences at The Chinese University of Hong Kong (CUHK) won gold at the International Genetically Engineered Machine (iGEM) 2010 competition organized by the Massachusetts Institute of Technology (MIT) in the US. Under the supervision of Prof. Chan King-ming, Prof. Chan Ting-fung and Prof. Kong Siu-kai of the School of Life Sciences, the CUHK team significantly advanced the use of bacteria for information storage by strengthening its storage capacity and security system. An innovative biological cryptography system for application in DNA is developed to protect information leakage, heralding a new era of information security.

At a celebration held today (24 November), Prof. Joseph J. Y. Sung, CUHK Vice-Chancellor, congratulated the students and the newly-established School of Life Sciences on their achievement. ‘The competition encourages students to develop research projects to benefit mankind with their creativity and wisdom. It also broadens their horizons by promoting inter-disciplinary learning.’

Using bacteria as an information storage device was proposed about a decade ago. However, the award-winning CUHK team was the first to use the plasmid DNA of Escherichia coli to encrypt and store information not only in the form of text, but also in the forms of images, biological barcodes, etc.

In order to store a massive amount of data, the team proposed to fragment the information and store them in bacteria. A novel information processing system was invented to reconstruct the original information. With this technology, it is estimated that one gram of bacteria can store data of up to 900,000 GB (gigabytes), which is equivalent to 450 hard drives, each with 2 TB (terabytes) of storage capacity.  The biocryptography system has a great potential for long term and large scale data storage, and is also applicable to the production of genetically modified food and organisms.

Prof. Chan King-ming is very pleased with the students’ result. ‘The team was formed early this year, and members have spent endless hours during the past 10 months developing the research project from scratch – from designing experiments, testing out the idea, to creating a website and poster, and presenting in front of a panel of judges.’ The team was led by three instructors – Yu Chi-shing, Li Jing-woei and Yim Kay-yuen Aldrin, and was composed of eight students – Loo Fong-chuen Jacky, Choi Ricky Thomson, Chu Tin-yi, Wong Kit-ying, Chiu Wai-yin Vivien, Mak Ka-yan Cathy, Liu Si-si Sophie and Wong In-chun Ada.


About iGEM Competition

iGEM is the premier synthetic biology competition for undergraduates worldwide.  It began in January 2003 as a month-long course for students to design biological systems, and grew into a competition in 2004. For iGEM 2010, 138 teams with over 1,900 participants from around the world took part.  They are required to specify, design, build, and test simple biological systems made from standard, interchangeable biological parts.  The accomplishments of these student teams often lead to important advances in medicine, energy, and the environment.  

For more information, please visit http://www.igem.ord

iGEM-photos

>> iGEM CUHK Team Website
>> Team Members
>> More Photos

 

Our academic staff are active and excellent in research. Our research areas include:
   
   - Cell Biology
   - Environmental Science
   - Food & Nutritional Sciences
   - Genomics and bioinformatics
   - Marine Science
   - Plant & Agricultural Science
   - Physiology & Developmental Biology
   - Protein Science
   - Toxicology

The School also manages various research centers including:

   
   - Centre for Cell and Developmental Biology
   - Food Research Centre of The Chinese University of Hong Kong
   - Simon FS Li Marine Science Laboratory
   - The Centre for Protein Science and Crystallography
   - The Croucher Laboratory for Human Genomics
   - The Hong Kong Bioinformatics Centre
   - UGC-AoE Centre for Plant & Agricultural Biotechnology

Our research in Cell Biology covers a wide variety of research themes including apoptosis, cell structure and function, cell signaling, stem cell biology, neurobiology etc. The basic principles and questions in the fields are explored by using well-recognized cell systems, top model organisms and a variety of advanced technologies.   Model Organism

 

Cancer cells were discovered to be capable of recovering after exposure to a chemical cocktail which triggers apoptosis -- a cell suicide process. This finding could potentially help the development of new, more effective anti-cancer drugs.

 

cancer image

 

Fung   Confocal microscopy and transgenic tobacco cell lines were used to study protein trafficking and cell organelles in plants

26 October 2012

CUHK Students Win Gold Medal at iGEM Asia Again
Heading to US Next Month for World Championship


Following last year's success, the iGEM (international Genetic Engineered Machine) team of The Chinese University of Hong Kong (CUHK) has won a gold medal again at the iGEM Asia Regional Jamboree, and is qualified to participate in the iGEM World Jamboree to be held at the Massachusetts Institute of Technology next month. The team consists of 9 students from the School of Life Sciences, 6 students from the Faculty of Engineering and 5 instructors. Since this May, the CUHK team had been devoted to preparing for the competition and developed the project completely by themselves, from defining themes, designing experiments to developing new parts and models from scratch. They demonstrated ample team spirit and efforts included publishing a wiki page, producing posters and introducing the project and the new devices on public occasions.

In their award-winning project 'Light of No Return', the CUHK team has created bacteria harbouring rhodopsin to attract cells with different light spectra for cell sorting. The idea is to allow bacteria to 'see' and sense light source, so that light could be used to attract or separate bacteria. This technology may be used to improve the efficacy of chemical treatment such as water sewage treatment. The team has also successfully made new biobricks with introduce 'bacterial killing' DNA to enhance biosafety. These bacterial killing biobricks can enhance biosafety by preventing the proliferation of transformed bacteria and antibiotic resistant bacteria, which are also known as the super bugs. For details of the project, please visit the following links:
http://2012.igem.org/Team:Hong_Kong-CUHK
http://2012.igem.org/files/presentation/Hong_Kong-CUHK.pdf 

In addition, members of the CUHK team also organized various high school outreach activities to introduce to high school students the potential social implications and significance in academic research of genetic engineering and synthetic biology through talks and workshops, with an aim to enhance their understanding and to raise their interests in this field. The team will also introduce synthetic biology and their project to the public at the University's Orientation Day on coming Saturday (27 October). 

About iGEM Competition 

iGEM is an annual premier synthetic biology competition for undergraduates worldwide. It was established by the MIT in 2004 to foster students’ learning in synthetic biology, promote collaboration among students and nurture biology talents. Participating teams are required to specify, design, build, and test simple biological systems made from standard, interchangeable biological parts. The accomplishments of these student teams often lead to important advances in medicine, energy, and the environment. For more information, please visit http://www.igem.org.

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二零一二年十月二十六日

中大生再奪國際遺傳工程機器設計競賽亞洲區金獎
下月赴美參加世界賽


香港中文大學(中大)遺傳工程機器隊伍延續去年佳績,日前在國際遺傳工程機器設計競賽(iGEM)亞洲區比賽中再奪金獎,並將於下月赴美國麻省理工學院參加世界決賽。中大隊伍由9名生命科學學院的學生、6名工程學院學生及5名教練組成。他們自今年五月起已積極作好準備,由訂定題目到創造生物零件及模型,以及設計實驗,皆完全由學生自行創作。在亞洲區比賽當天,各隊員分工合作,除完成實驗外,還要製作網頁及海報,並在公開演說中講解其創作的課題,終獲得理想成績。 

中大隊伍的參賽研究項目名為「見光不回頭」 (Light of No Return)。隊員別具創意,利用能夠辨別顏色的蛋白注入細菌內,把不能看東西的細菌加上可感光的「眼睛」。此構思可利用不同光譜吸引或者分離細菌,有助污水處理如吸收污染物或提高分解污染物的效益。中大隊伍同時引進了能注入基因片斷進行殺菌的新生物零件,提高生物安全性,可防止抗藥惡菌肆虐,亦可阻止轉基因細菌擴散,具醫療應用的價值。有關研究項目的詳細內容,可參考以下連結:
http://2012.igem.org/Team:Hong_Kong-CUHK
http://2012.igem.org/files/presentation/Hong_Kong-CUHK.pdf 

此外,參賽隊伍成員於比賽後亦舉辦了中學外展活動,透過講座及實驗工作坊向高中生介紹遺傳工程及合成生物學技術,及其對社會或學術研究的貢獻,加深他們對此學科的興趣。隊員亦將於本周六(10月27日)舉行的本科生入學資訊日向公眾介紹有關知識。 

iGEM比賽簡介

iGEM比賽為國際合成生物學界每年一度的盛事,專為本科生而設。iGEM由麻省理工學院於2004年創立,旨在促進學生在合成生物學的學習、交流與合作,以培養合成生物學人才。比賽隊伍須利用基本且可交替的生物部件,設計及建立有效的生物系統。參賽作品水平超卓,有效推動醫學、能源及環境等方面的發展。網址:http://www.igem.org

 

 igem2012webcover

>>iGEM 2012 CUHK Team Website
>>Team Members
>>Photo Albums   Videos: i. Presentation  ii. Q & A